Pseudo Chediak Higashi-like inclusions in myeloblasts in AML-M2

Pseudo Chediak-Higashi Anomaly

A 9-year-old girl was admitted to hospital with a 1-month history of fever, weight loss, epistaxis, and abdominal pain. The girl’s parents were non-consanguineous. Her medical history was unremarkable. Upon admission she weighed 27 kg (25th-50th percentile), was 131 cm tall (50th percentile), and was pale. Physical examination showed multiple cervical and inguinal microlymphadenopathies, withou...

Pseudo-Chediak-Higashi inclusions in a case of acute lymphoblastic leukemia

Chediak-Higashi–Like Granules in Acute Promyelocytic Leukemia

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

Chediak-Higashi-like granules in acute promyelocytic leukemia.

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

Chediak-Higashi Syndrome

Impaired vision Photophobia Albinism of the OCA2 type, giving a lighter complexion than unaffected family members [6] Silvery sheen to hair which may be fair in colour Frequent infections (skin, mucous membranes, respiratory) Epilepsy Mental retardation Enlarged liver and spleen Jaundice Ataxia causing incoordination and a typical ataxic gait Tremor Epilepsy Peripheral neuropathy causing motor ...